Fascin-1 in Cancer Cell Metastasis: Old Target-New Insights

As metastasis is responsible for most cancer-related deaths, understanding the cellular and molecular events that lead to cancer cell migration invasion will certainly provide insights into novel anti-metastatic therapeutic targets. Fascin-1 an actin-bundling protein fundamental all physiological or pathological processes require migration. It cross-linking actin microfilaments during formation of actin-rich structures at leading edge migrating cells such as filopodia, lamellipodia invadopodia. While epithelial tissues express low levels Fascin-1, it dramatically elevated in majority cancers its expression has been associated with more aggressive disease decreased overall survival. Hence, proposed a potential anti-cancer target. In present review, we studied recent literature regard different cancers, role altering mechanical properties cells, promoting migration, effect inhibition, via various pharmacological inhibitors, eliminating vitro and/or vivo. Recent studies corroborate notion critically involved prove valuable target worth investigating further.